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Expression of E‐cadherin in normal, hyperplastic and neoplastic feline mammary tissue
Author(s) -
Dias Pereira P.,
Gärtner F.
Publication year - 2003
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.153.10.297
Subject(s) - myoepithelial cell , pathology , immunohistochemistry , immunostaining , cadherin , epithelium , biology , cribriform , staining , cytoplasm , hyperplasia , neoplastic cell , cell , medicine , microbiology and biotechnology , genetics
This paper describes an immunohistochemical study of the expression of E‐cadherin in four samples of normal, eight samples of hyperplastic and 19 samples of neoplastic feline mammary tissue. In the normal tissues, the luminal epithelial cells showed a strong pattern of staining for E‐cadherin at the cell‐cell boundaries, whereas the myoepithelium showed no immunoreactivity. In the hyperplastic tissues and the five benign neoplasms, there were disturbances in the expression of E‐cadherin in the luminal epithelium, in the form of the coexistence of membranous and cytoplasmic staining, together with immunoreactivity in a small percentage of myoepithelial cells. In 11 of 14 carcinomas, there was a reduction or absence of E‐cadherin expression and abnormalities in the pattern of immunostaining; these changes were more pronounced in cribriform and solid carcinomas.