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Immunohistochemical study of the expression of E‐cadherin in canine mammary tumours
Author(s) -
Reis A. L.,
Carvalheira J.,
Schmitt F. C.,
Gärtner F.
Publication year - 2003
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.152.20.621
Subject(s) - immunohistochemistry , pathology , cadherin , mammary gland , biology , medicine , cancer , cell , breast cancer , genetics
To investigate the possible role of E‐cadherin in canine mammary tumours 20 benign and 40 malignant tumours were evaluated by immunohistochemistry in formalin‐fixed paraffin wax‐embedded samples. In all the benign tumours, E‐cadherin was strongly expressed at the intercellular borders of epithelial cells, but it was less strongly expressed in 17 (43 per cent) of the malignant tumours. Furthermore, poorly differentiated carcinomas were less immunoreactive for E‐cadherin than moderately and well differentiated carcinomas.