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Reduced dosage of ketoprofen for the short‐term and long‐term treatment of joint pain in dogs
Author(s) -
Hazewinkel H. A. W.,
Brom W. E.,
Theijse L F. H.,
Pollmeier M.,
Hanson P. D.
Publication year - 2003
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.152.1.11
Subject(s) - ketoprofen , medicine , analgesic , synovitis , anesthesia , adverse effect , arthritis , pharmacology
Two studies were conducted under laboratory conditions with 16 dogs to investigate the analgesic effectiveness of a low dose of ketoprofen in a short‐term sodium urate crystal‐induced synovitis model of arthritis. The effect of the treatment, defined as the improvement in peak vertical force weight bearing, was evaluated in the first study at three dose levels. A single oral dose of 0.25 mg/kg ketoprofen was significantly better (P<0.01) than the control (0 mg), but doses of 0.5 and 0.75 mg/kg did not improve the dogs' weight bearing further. The second study investigated the efficacy and safety of the 0.25 mg/kg dose administered daily for 30 days. The beneficial effects of ketoprofen at this dose were constant, with the treated dogs bearing 89.1 per cent of the baseline vertical force four hours after the induction of arthritis on day 1 and 92.2 per cent on day 29, compared with 42 per cent and 34 per cent of the baseline in the untreated dogs. No gastrointestinal or other side effects were observed during the treatment.