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Discriminant value of blood and urinary corticoids for the diagnosis of scrapie in live sheep
Author(s) -
PicardHagen N.,
Gayrard V.,
Laroute V.,
Grandjean C.,
Toutain P. L.,
Andreoletti O.,
Schelcher F.,
Elsen J. M.
Publication year - 2002
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.150.22.680
Subject(s) - scrapie , creatinine , urine , urinary system , medicine , mean value , veterinary medicine , endocrinology , biology , zoology , disease , mathematics , prion protein , statistics
The mean (sd) concentration of plasma 20β‐dihydrocortisol in 126 scrapie.affected sheep was 5.5 (7.0) ng/ml compared with 1.1 (0.7) ng/ml in 52 healthy sheep. The mean (sd) concentration of creatinine in the urine of 93 scrapie.affected sheep was 2.43 (1.56) pg/ml compared with 0.94 (0.86) μg/mI in 49 healthy sheep and 1.10 (0.95) μg/ml in 25 sheep with other diseases. These discriminant analyses carried out on healthy and scrapie.affected sheep showed that plasma 20β‐dihydrocortisol and urinary creatinine were the best predictors of the disease, and classified correctly 98 per cent of healthy sheep and 82 per cent of scrapie.affected sheep.