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Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mammary glands and spontaneous mammary tumours
Author(s) -
Geraldes M.,
Gärtner F.,
Schmitt F.
Publication year - 2000
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.146.14.403
Subject(s) - immunohistochemistry , receptor , mammary gland , hormone , biology , monoclonal antibody , malignancy , progesterone receptor , medicine , endocrinology , pathology , cancer , antibody , estrogen receptor , breast cancer , immunology
The expression of hormone receptors and their relationship_to cell proliferation in six samples of normal canine mammary tissue, and 11 benign and 10 malignant mammary neoplasms from female dogs were assessed by immunohistochemistry in formalin‐fixed paraffin‐embedded samples, by using monoclonal antibodies against progesterone and oestrogen receptors, and nuclear antigen Ki‐67 (MIB‐1). Malignant tumours negative for progesterone receptors proliferated at higher rates than progesterone receptorpositive tumours, suggesting that the progression towards malignancy in spontaneous mammary tumours is accompanied by a decrease in hormonal steroid dependency. Only one malignant tumour was positive for oestrogen receptors.