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Evaluation of secondary haemostasis in canine leishmaniasis
Author(s) -
Moreno P.
Publication year - 1999
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.144.7.169
Subject(s) - canine leishmaniasis , leishmaniasis , medicine , virology , visceral leishmaniasis , immunology , leishmania infantum
Secondary haemostasis was evaluated in 26 dogs with leishmaniasis and 10 normal dogs by measurements of modified one‐stage prothrombin time (m‐OSPT), activated partial thromboplastin time (APTT), thrombin time, fibrinogen concentration and fibrin degradation products. There were no significant differences between the groups in the m‐OSPT, fibrinogen concentration, or levels of fibrin degradation products. The AM was significantly (P=0.006) longer in the infected dogs than in the control group, and in infected dogs with alanine aminotransferase (ALT) activities >50 U/litre. There was a significant linear regression between ALT and AM. Thrombin time was significantly (P=0.003) longer in the infected dogs than in the normal dogs. There were no significant differences between the thrombin times of sick dogs with different levels of creatinine or activities of ALT, or between male and female dogs, whether diseased or normal.