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Clindamycin hydrochloride and clavulanate‐amoxycillin in the treatment of canine superficial pyoderma
Author(s) -
Littlewood D.,
Lakhani K. H.,
Paterson S.,
Wood J. L. N.,
Chanter N.
Publication year - 1999
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.144.24.662
Subject(s) - clindamycin , medicine , pyoderma , amoxicillin , antibiotics , dermatology , surgery , microbiology and biotechnology , biology
A masked, randomised, controlled clinical trial for the treatment of canine superficial pyoderma was undertaken. Dogs with a clinical diagnosis of superficial pyoderma, supported by bacterial culture were admitted to the trial and randomly assigned to treatment with either clindamycin hydrochloride at 5.5 mg/kg twice daily or clavulanate‐amoxycillin at 12.5 mg/kg twice daily. After 21 days the animals were re‐assessed, and therapy was continued for a further 21 days in the dogs with persistent lesions if bacterial culture demonstrated continued sensitivity. Twenty‐nine dogs were treated with clindamycin hydrochloride and 27 with clavulanate‐amoxycillin. Complete cure was obtained after three weeks in 17 (59 per cent) of the clindamycin‐treated cases, but in only eight (30 per cent) of the clavulanate‐amoxycillin treated group. Clindamycin was significantly more effective than clavulanate‐amoxycillin for the treatment of superficial pyoderma in dogs.