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Anthelmintic induced congenital malformations in sheep embryos using netobimin
Author(s) -
Navarro M.,
Cristofol C.,
Carretero A.,
Arboix M.,
Ruberte J.
Publication year - 1998
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.142.4.86
Subject(s) - anthelmintic , benzimidazole , congenital malformations , embryo , pregnancy , teratology , medicine , dissection (medical) , biology , physiology , gestation , anatomy , veterinary medicine , chemistry , genetics , organic chemistry
Benzimidazole compounds have teratogenic effects in domestic and experimental animals. In this study, 14 Manchega ewes were treated orally, under controlled conditions, with 20 mg netobimin (a prodrug of a benzimidazole compound) per/kg bodyweight on the 17th day of pregnancy. Congenital malformations and abortions affected 60 per cent of the lambs. The main malformations were skeletal and renal, but vascular malformations were observed for the first time. The abnormalities were investigated using radiological, dissection and vascular injection techniques, and associations among them were recorded. The anomalies are discussed in terms of embryological considerations.