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DNA marker C04107 for copper toxicosis in a population of Bedlington terriers in the United Kingdom
Author(s) -
Holmes N. G.,
Herrtage M. E.,
Ryder E. J.,
Binns M. M.
Publication year - 1998
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.142.14.351
Subject(s) - allele , breed , microsatellite , locus (genetics) , disease , genetic marker , liver biopsy , population , pathology , medicine , biopsy , biology , genetics , gene , environmental health
The DNA microsatellite marker C04107, linked to the Bedlington terrier copper toxicosis locus, is used diagnostically in the USA to detect the disease allele. This marker has been typed in Bedlington terriers of known disease status in the United Kingdom, and it is concluded that it should be useful in eradicating the disease from the breed in the UK. The marker also identified a dog which had been diagnosed on the basis of a liver biopsy as having the disease, as being unaffected; a second liver biopsy confirmed that the dog did not have copper toxicosis.