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Treatment of a dog with an insulinoma‐related peripheral polyneuropathy with corticosteroids
Author(s) -
Van Ham L.,
Braund K. G.,
Roels S.,
Putcuyps I.
Publication year - 1997
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.141.4.98
Subject(s) - insulinoma , medicine , polyneuropathy , peripheral , paresis , pathogenesis , ambulatory , peripheral neuropathy , pancreas , gastroenterology , endocrinology , diabetes mellitus , surgery
A crossbreed dog with a history of a chronic progressive tetra‐paresis had an insulinoma‐related peripheral polyneuropathy. Frequent feeding and treatment with corticosteroids resulted in recovery from a non‐ambulatory to an almost completely normal clinical state, despite the persistence of hypoglycaemia and hyperinsulinism. After euthanasia for uncontrollable seizures, the presence of a beta‐cell carcinoma of the pancreas and extensive axonal degeneration of the peripheral nerves was confirmed by histopathological examination. These findings may indicate an immune‐mediated pathogenesis for insulinoma‐related peripheral polyneuropathy.