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Antithrombin‐III activity in plasma of healthy and sick cattle
Author(s) -
Pusterla N.,
Braun U.,
Forrer R.,
Lutz H.
Publication year - 1997
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.140.1.17
Subject(s) - medicine , antithrombin , gastroenterology , coagulopathy , quartile , heparin , confidence interval
Antithrombin‐III (AT‐III) activity was determined in the plasma of 32 healthy cows. The range of activities was between 105 and 160 per cent of a human reference plasma; the median activity was 132.5 per cent, and the 5 per cent and the 95 per cent quartiles were 111.1 per cent and 153.9 per cent of the standard. The activity of AT‐III was also determined in 82 cows with a variety of internal diseases. In cows with hepatopathy, acute enteritis, generalised peritonitis, blood loss, idiopathic cardiomyopathy, glomerulonephritis and disseminated coagulopathy, the activity of AT‐III was lower than in healthy animals. The lower values were due to decreased synthesis, increased consumption, or the loss of AT‐III. An acquired deficiency of AT‐III appears to favour the development of thrombophlebitis.