Premium
Side effects of oral antimicrobial agents in the horse: a comparison of pivampicillin and trimethoprim/sulphadiazine
Author(s) -
Ensink J. M.,
Klein W. R.,
Barneveld A.,
Miert A. S. J. P. A. M.,
Vulto A. G.
Publication year - 1996
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.138.11.253
Subject(s) - trimethoprim , antimicrobial , medicine , horse , adverse effect , oral administration , sulfamethoxazole , diarrhea , feces , antibiotics , microbiology and biotechnology , biology , paleontology
To evaluate the side effects of oral pivampicillin and trimethoprim/sulphadiazine, 200 horses receiving these antimicrobial agents were studied. The horses received either trimethoprim/sulphadiazine (30 mg/kg twice daily) or pivampicillin (25 mg/kg twice daily) for three or more days. No adverse effects other than loose faeces and diarrhoea were detected. The risk of diarrhoea was significantly less after the oral administration of pivampicillin (3 per cent) than after trimethoprim/sulphadiazine (7 per cent). Horses whose appetite was reduced appeared to be predisposed to develop diarrhoea after the administration of either oral antimicrobial agent.