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Discriminating transudates and exudates in dogs with pleural effusion: diagnostic utility of simplified Light's criteria compared with traditional veterinary classification
Author(s) -
Zoia Andrea,
Petini Matteo,
Righetti Danila,
Caldin Marco,
Drigo Michele
Publication year - 2020
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.105650
Subject(s) - pleural effusion , medicine , effusion , hydrostatic pressure , lactate dehydrogenase , lactic dehydrogenase , veterinary medicine , pathology , radiology , surgery , biology , biochemistry , physics , enzyme , thermodynamics
Objectives To determine whether the simplified Light's criteria (ie, pleural effusion lactate dehydrogenase concentration and serum total protein) can identify the pathophysiology of pleural effusion formation in dogs, and to assess whether these criteria were more accurate than the traditional veterinary classification based on pleural effusion total protein (TPp) and nucleated cell count (TNCCp). Methods This is a cross‐sectional study including 100 dogs with pleural effusion. The aetiology of effusion was used to classify the pathophysiology of its formation. Parameters measured included the simplified Light's criteria, TPp and TNCCp. The diagnostic utility of the two methods in classifying pleural effusion formation was evaluated. Results Seven transudates due to decreased colloid osmotic pressure, 18 transudates due to increased hydrostatic pressure gradient and 75 exudates were included in the study. The simplified Light's criteria misclassified 2 of 75 exudates (98 per cent overall accuracy). The traditional veterinary classification scheme misclassified 31 of 75 exudates and 12 of 18 increased hydrostatic pressure gradient transudates (57 per cent overall accuracy). The frequency of agreement between the simplified Light's criteria and the traditional veterinary classification with the true nature of the pleural effusion was significantly different (P<0.001). Clinical significance The simplified Light's criteria were highly accurate in discriminating exudates from transudates, while TPp and TNCCp had no diagnostic value in doing so.