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First report of prion‐related protein gene ( PRNT ) polymorphisms in cattle
Author(s) -
Kim YongChan,
Jeong ByungHoon
Publication year - 2018
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.104123
Subject(s) - hanwoo , prnp , single nucleotide polymorphism , genotype , biology , korean native , genetics , holstein cattle , prion protein , gene , exon , virology , microbiology and biotechnology , medicine , pathology , ecology , food science , disease
Prion diseases are caused by structural changes in normal prion protein (PrP C ). The prion gene family includes four members: prion protein ( PRNP ), prion‐like protein ( PRND ), shadow of PRNP ( SPRN ) and prion‐related protein ( PRNT ). Genetic association studies of prion diseases and the other genes in the prion gene family, except for PRNT , have been performed in cattle. Our previous studies indicated that the distribution of PRNP promoter polymorphisms related with bovine spongiform encephalopathy susceptibility is significantly different in Hanwoo (Korean native cattle) and Holstein cattle. However, PRNT polymorphisms have not been reported thus far in cattle. Hence, we examined the PRNT single nucleotide polymorphisms (SNPs) in 315 Hanwoo and 140 Holstein cattle. We found a total of two SNPs, PRNT c.‐87C>T and PRNT c.‐37G>C, in the 5’ untranslated region of exon 2. The c.‐87C>T and c.‐37G>C genotype (P<0.0001) and allele (P<0.0001) frequencies exhibited significant differences in the distribution between Hanwoo and Holstein cattle. In addition, the c.‐37G