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NetF‐positive Clostridium perfringens in neonatal foal necrotising enteritis in Kentucky
Author(s) -
Mehdizadeh Gohari I.,
Parreira V. R.,
Timoney J. F.,
Fallon L.,
Slovis N.,
Prescott J. F.
Publication year - 2016
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.103606
Subject(s) - medicine , foal , library science , veterinary medicine , geography , archaeology , computer science
TYPE A Clostridium perfringens has been associated with necrotising enteritis in 1–14-day-old foals in Kentucky (Donahue and Williams 2002, Timoney and others 2005) but the pathogenesis of the disease is not well understood, in part because few affected foals die and thus the availability of postmortem samples is rare. An autogenous bacterin-toxoid vaccine utilising a C. perfringens Type A strain (UK MF 05/00) that carries genes for the α toxin (CPA), β2 toxin (CPB2) and enterotoxin (CPE), further enriched with recombinant CPB2 toxin, is used to immunise mares on Kentucky breeding farms with histories of foal diarrhoea (Timoney and others 2005). Recently, a novel pore-forming toxin NetF has been strongly associated with foal necrotising enteritis and canine haemorrhagic gastroenteritis (Mehdizadeh Gohari and others 2015). Here, the authors report for the first time the identification of netF -positive type A C. perfringens in foals with enteritis and enterocolitis in Kentucky and …