Premium
Enteral administration of monosodium phosphate, monopotassium phosphate and monocalcium phosphate for the treatment of hypophosphataemia in lactating dairy cattle
Author(s) -
Idink M. J.,
Grünberg W.
Publication year - 2015
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1136/vr.102847
Subject(s) - monocalcium phosphate , chemistry , rumen , zoology , oral administration , phosphate , triphenyl phosphate , medicine , food science , biochemistry , biology , organic chemistry , fire retardant , fishery , fish <actinopterygii> , fermentation , fish meal
Hypohosphataemia is a frequent finding in early lactating and anorectic dairy cows. Sodium phosphate is commonly used for oral phosphorus (P) supplementation, although other phosphate salts may present useful treatment alternatives. Objectives of this study were to compare the efficacy of monopotassium phosphate (KH 2 PO 4 ) and monocalcium phosphate (Ca(H 2 PO 4 ) 2 ) to monosodium phosphate (NaH 2 PO 4 ) in P‐depleted cows. Furthermore, the effect of concentrated NaH 2 PO 4 on the reticular groove reflex was studied. Six healthy but P‐depleted dairy cows underwent four treatments in randomised order. Treatments consisted of intraruminal administration of NaH 2 PO 4 , KH 2 PO 4 and Ca(H 2 PO 4 ) 2 providing the equivalent of 60 g P. A fourth treatment consisting of concentrated NaH 2 PO 4 combined with acetaminophen as a marker substance was administered orally to determine whether the reticular groove reflex could be induced. Intraruminal administration of NaH 2 PO 4 and KH 2 PO 4 resulted in similar increases in plasma Pi concentrations ([Pi]) while intraruminal Ca(H 2 PO 4 ) 2 resulted in lower increases in plasma [Pi]. Oral and intraruminal administration of NaH 2 PO 4 resulted in similar times to peak plasma [Pi] and acetaminophen concentration, indicating that concentrated NaH 2 PO 4 administered orally did not trigger the reticular groove reflex. These results suggest that oral administration of KH 2 PO 4 is equally effective as NaH 2 PO 4 . Oral administration of Ca(H 2 PO 4 ) 2 in contrast has a less pronounced effect on the plasma [Pi].