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Unexpected but transient tumour enlargement preceded complete regression and long‐term control after irradiation of squamous cell carcinoma in a red‐eared slider ( Trachemys scripta elegans )
Author(s) -
Baja Alexie J,
Lewbart Gregory A,
Luff Jennifer A,
Nolan Michael W
Publication year - 2020
Publication title -
veterinary record case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.165
H-Index - 4
ISSN - 2052-6121
DOI - 10.1136/vetreccr-2019-001039
Subject(s) - medicine , debulking , lesion , radiation therapy , basal cell , stage (stratigraphy) , brachytherapy , pathology , surgery , cancer , biology , paleontology , ovarian cancer
A red‐eared slider with a chronic non‐healing ulcerative shell lesion was diagnosed with cutaneous squamous cell carcinoma (SCC). The animal underwent surgical debulking and adjuvant hypofractionated radiation therapy. The lesion initially responded, with near‐complete tumour regression, but then began growing again just a few months after finishing radiotherapy. Then, after several months with no additional tumour‐directed therapy, the lesion again regressed. Five years post‐irradiation and with no further treatment, the turtle now remains tumour‐free. This unusual pattern of disease regression, followed by transient growth and then long‐term local tumour control, suggests either a spontaneous remission or a pseudoprogression‐like phenomenon. Careful clinical follow‐up and reporting of future cases will aid in determining whether this pseudoprogression‐like event was random, versus being a common component of the chelonian response to irradiation of cutaneous SCC.