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High‐grade astrocytoma with ventricular invasion in a dog
Author(s) -
Pupin Rayane Chitolina,
Rissi Daniel R,
Gomes Danilo Carloto,
Gimelli Amanda,
Palumbo Mariana Isa Poci
Publication year - 2019
Publication title -
veterinary record case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.165
H-Index - 4
ISSN - 2052-6121
DOI - 10.1136/vetreccr-2019-000958
Subject(s) - pathology , medicine , astrocytoma , immunohistochemistry , neuropil , olig2 , anatomy , stroma , ventricle , glioma , central nervous system , oligodendrocyte , myelin , cancer research
A 13‐year‐old female German Shepherd dog was euthanised and submitted to necropsy after a 7‐month history of prolonged recumbency and vocalisation. Gross anatomical changes consisted of a well‐demarcated, 3.5×1.5 cm, soft red mass that effaced the right lateral ventricle and compressed the adjacent neuroparenchyma. Histologically, elongate neoplastic cells with astrocytic morphology were arranged in short bundles and streams supported by a neuropil‐like stroma. Neoplastic cells were immunopositive for glial fibrillar acidic protein (GFAP) and oligodendrocyte transcription factor 2 (Olig2), and immunonegative for e‐cadherin and pancytokeratin. Histological and immunohistochemical features were consistent with a high‐grade astrocytoma with ventricular invasion, a rare feature of astrocytic tumours in dogs.