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Imaging and histopathological characteristics of carcinoma‐induced bone formation in skeletal muscle
Author(s) -
Luce Brooke,
Magagna Michelle,
Policelli Smith Rachel,
Vilar Saavedra Paulo
Publication year - 2019
Publication title -
veterinary record case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.165
H-Index - 4
ISSN - 2052-6121
DOI - 10.1136/vetreccr-2018-000739
Subject(s) - medicine , lameness , ossification , pathology , anatomy , biopsy , carcinoma , trunk , radiology , ecology , biology
An 11‐year‐old neutered male Groenendael canine presented with suspected neoplastic disease associated with pelvic limb lameness. Clinical examination revealed firm and thickened ventral abdominal musculature, pitting oedema with a spiculated texture within pelvic limb and inguinal subcutaneous tissues, sublumbar lymphadenopathy and multifocal hard foci along the floor of the pelvic canal. CT revealed a severe active polyostotic periosteal reaction and muscular mineralisation of the hindlimbs and caudal trunk. Skeletal muscle biopsy revealed a histopathological diagnosis of metastatic carcinoma with chondroid osseous metaplasia characterised by ossification (bone formation) within the tissue matrix. Paliative therapy was provided for the dog for two weeks before being euthanized.