Premium
Delayed hypersensitivity reaction to human serum albumin in a dog surgically managed for septic peritonitis
Author(s) -
Hubers Mike,
Allison Asher,
Vallefuoco Rosario
Publication year - 2019
Publication title -
veterinary record case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.165
H-Index - 4
ISSN - 2052-6121
DOI - 10.1136/vetreccr-2018-000722
Subject(s) - medicine , surgery , prednisolone , jaundice , anesthesia , anaphylaxis , allergy , immunology
A five‐year‐eight‐month‐old standard poodle presented with hypovolaemic shock and severe jaundice. The dog was diagnosed with a perforating pyloric ulcer and treated surgically with pylorectomy and gastroduodenostomy. During the recovery phase the dog developed peripheral oedema secondary to severe hypoalbuminaemia (14 g/l). Treatment of the hypoalbuminaemia included a human serum albumin (HSA) transfusion. The patient was readmitted nine days post‐transfusion with pyrexia, petechiae, scleral bleeding, anorexia, oedema and forelimb lameness. A presumptive diagnosis of a type 3 hypersensitivity reaction to the HSA transfusion was made. The dog was treated with 0.5 mg/kg prednisolone twice daily, 20 mg/kg pentoxifylline three times a day and 1 mg/kg omeprazole twice daily. Clinical signs resolved within one week, and at the last follow‐up, five months postsurgery, the owners reported that the dog was clinically well with no further signs of side effects from the HSA transfusion.