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Marked paraneoplastic hypereosinophilia associated with a low‐grade, metastatic canine mast cell tumour
Author(s) -
Musser Margaret,
Berger Erika,
Flaherty Heather A,
Fox Leslie,
Johannes Chad M
Publication year - 2018
Publication title -
veterinary record case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.165
H-Index - 4
ISSN - 2052-6121
DOI - 10.1136/vetreccr-2017-000563
Subject(s) - hypereosinophilia , medicine , pathology , eosinophilic , lymph node , mast cell , lymph , metastasis , chemotherapy , eosinophilia , immunology , cancer
An 11‐year‐old, female, spayed labrador retriever was presented to the Iowa State University Oncology Service for evaluation of a rapidly expanding mass located near the right prescapular lymph node. A Patnaik grade I mast cell tumour (mitotic index <3/10 high‐power fields) had been completely excised from the right antebrachium five months before presentation. Cytological evaluation of aspirates from the healed incision site and the new mass revealed mast cells with marked eosinophilic infiltration consistent with local recurrence and presumed lymph node metastasis. A complete blood count revealed markedly elevated eosinophils (23.96×10 3 cells/µl, reference interval 0–0.75). The patient was diagnosed with a histologically low‐grade, biologically high‐grade cutaneous, metastatic mast cell tumour with paraneoplastic hypereosinophilia. Changes in the magnitude of peripheral hypereosinophilia frequently paralleled tumour response to treatment with multiple antineoplastic agents. Nine months after initiating chemotherapy, treatment was discontinued due to declining quality of life.