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Metastasising hepatic neuroendocrine carcinoma in a pygmy goat (Capra hircus hircus )
Author(s) -
Völker Iris,
Kummrow Maya,
Dörnberg Katja,
Wohlsein Peter,
HewickerTrautwein Marion
Publication year - 2015
Publication title -
veterinary record case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.165
H-Index - 4
ISSN - 2052-6121
DOI - 10.1136/vetreccr-2015-000196
Subject(s) - medicine , lameness , pathology , dermis , metastasis , capra hircus , chromogranin a , claw , granulation tissue , histopathological examination , immunohistochemistry , anatomy , wound healing , surgery , cancer , biology , veterinary medicine , ecology
An adult, female pygmy goat showed clinical injury and later lameness caused by marked swelling and ulceration of the left lateral hind claw. Conservative treatments failed and due to the development of excessive granulation tissue the lateral claw was amputated. Histologically, a malignant tumour invading the dermis was diagnosed. Fourteen weeks after surgery the goat became recumbent, showed increased values of liver enzymes. Euthanasia followed for humane reasons. At postmortem examination, the liver tissue was almost completely replaced by a solid tumour mass. Additional neoplastic nodules were found in several organs and lymph nodes. Histological and immunohistochemical examination revealed a primary metastasising hepatic neuroendocrine carcinoma (PHNEC) expressing chromogranin A and neuron‐specific enolase. Neuroendocrine carcinomas have not been described in goats yet. A metastasis in the claw was the first clinical sign observed in this case. Pedal tumour metastasis should be considered as a differential diagnosis for lameness in goats.