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Fanconi syndrome in a Bichon Maltese dog: a quantitative approach to acid–base analysis
Author(s) -
MesaSánchez Ignacio,
Purzycka Katarzyna,
IsidoroAyza Marcos,
Ruiz de GopeguiFernández Rafael
Publication year - 2014
Publication title -
veterinary record case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.165
H-Index - 4
ISSN - 2052-6121
DOI - 10.1136/vetreccr-2013-000022
Subject(s) - medicine , fanconi syndrome , polyuria , metabolic acidosis , aminoaciduria , endocrinology , anion gap , acidosis , polydipsia , hyponatremia , proteinuria , renal tubular acidosis , metabolic alkalosis , alkalosis , base excess , gastroenterology , urine , kidney , diabetes mellitus
A three‐year‐old female Bichon Maltese dog presented with inappetence, polyuria, polydipsia, weakness, weight loss, seborrhoea and hypotrichosis. Diagnostic test results were consistent with Fanconi syndrome (euglycaemic glucosuria, hypophosphataemia, hyponatraemia, hypokalaemia, normal anion gap metabolic acidosis, proteinuria, aminoaciduria and increased urinary excretion of electrolytes). The dog died eight months after diagnosis and histopathological findings consisted of diffuse renal tubular necrosis. Fanconi syndrome is a rare disorder in veterinary medicine associated with a reabsorption defect of the proximal renal tubules, resulting in renal tubular acidosis. A quantitative approach to acid–base analysis was applied in this patient. Initial presentation of acidaemia was mainly due to hyponatraemia (increased free water effect) and increased Cl − effect. The severe acidaemia observed seven months after initial presentation was primarily associated with hypoperfusion (raised lactate effect), increased unmeasured anions effects and hyponatraemia. A quantitative approach could be more appropriate than a traditional approach in Fanconi syndrome because it considers more of the individual factors affecting the acid–base balance (sodium, chloride, lactate, albumin, phosphate and unmeasured anions), all of which are altered in affected patients.