Open AccessBenzene-associated immunosuppression and chronic inflammation in humans: a systematic review
Author(s) -
Helen Guo,
Stacy Ahn,
Luoping Zhang
Publication year - 2020
Publication title -
occupational and environmental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.458
H-Index - 141
eISSN - 1470-7926
pISSN - 1351-0711
DOI - 10.1136/oemed-2020-106517
Subject(s) - proinflammatory cytokine , immune system , immunosuppression , immunosurveillance , immunology , medicine , inflammation , cancer , lymphoma
Recent evidence has accumulated that the immune system is intimately intertwined with cancer development. Two key characteristics of carcinogens in which the immune system plays a central role are chronic inflammation and immunosuppression. In this systematic review, we investigated the association of chronic inflammatory and immunosuppressive outcomes with benzene, a widely used industrial chemical. Benzene has been confirmed to cause acute myeloid leukaemia and suspected to cause non-Hodgkin lymphoma, two cancers of the blood-forming system that affect immune cells.