Open AccessQuantifying the mechanical and histological properties of thrombus analog made from human blood for the creation of synthetic thrombus for thrombectomy device testing
Author(s) -
W Merritt,
Anne Marie Holter,
Sharna Beahm,
C. Hernandez Gonzalez,
T Becker,
Aaron J. Tabor,
Andrew F Ducruet,
Laura S Bonsmann,
Trevor Cotter,
Sergey Frenklakh
Publication year - 2018
Publication title -
journal of neurointerventional surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.652
H-Index - 55
eISSN - 1759-8486
pISSN - 1759-8478
DOI - 10.1136/neurintsurg-2017-013675
Subject(s) - thrombus , medicine , human blood , biomedical engineering , ex vivo , surgery , in vivo , physiology , microbiology and biotechnology , biology
Untreated ischemic stroke can lead to severe morbidity and death, and as such, there are numerous endovascular blood-clot removal (thrombectomy) devices approved for human use. Human thrombi types are highly variable and are typically classified in qualitative terms - 'soft/red,' 'hard/white,' or 'aged/calcified.' Quantifying human thrombus properties can accelerate the development of thrombus analogs for the study of thrombectomy outcomes, which are often inconsistent among treated patients.