Open AccessConcomitant coiling reduces metalloproteinase levels in flow diverter-treated aneurysms but anti-inflammatory treatment has no effect
Author(s) -
Evan Thielen,
Megan McClure,
Aymeric Rouchaud,
Yong Hong Ding,
Daying Dai,
Dana Schroeder,
Juan R. Cebral,
David F. Kallmes,
Ramanathan Kadirvel
Publication year - 2016
Publication title -
journal of neurointerventional surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.652
H-Index - 55
eISSN - 1759-8486
pISSN - 1759-8478
DOI - 10.1136/neurintsurg-2015-012207
Subject(s) - concomitant , medicine , matrix metalloproteinase , ciclosporin , mmp9 , gastroenterology , chemotherapy , downregulation and upregulation , biology , biochemistry , gene
Flow diverters (FD) can cause rare but devastating delayed aneurysm ruptures in which matrix metalloproteinases (MMPs) have been potentially implicated. Concomitant coiling or anti-inflammatory medications have been proposed to prevent the risk of delayed ruptures. The aim of this study was to evaluate concomitant coiling and ciclosporin in regulating the expression of MMPs in FD-treated aneurysms.