Open AccessReceptor activator of NF-kappaB ligand (RANKL) is expressed in chondroblastoma: possible involvement in osteoclastic giant cell recruitment
Author(s) -
Lin Huang,
Y.Y. Cheng,
Louis T. C. Chow,
Minghao Zheng,
S. M. Kumta
Publication year - 2003
Publication title -
molecular pathology
Language(s) - English
Resource type - Journals
eISSN - 1472-4154
pISSN - 1366-8714
DOI - 10.1136/mp.56.2.116
Subject(s) - rankl , chondroblastoma , activator (genetics) , receptor , nf κb , cancer research , microbiology and biotechnology , biology , medicine , signal transduction , pathology , genetics
Chondroblastoma is a rare, locally aggressive bone tumour that causes osteolytic destruction at the epiphyseal end of the affected bone. It is possible that tumour cells may stimulate osteoclastogenesis and osteolytic destruction through the production of receptor activator of NF-kappaB ligand (RANKL), which is a key molecule essential for regulating osteoclast formation and activity. Therefore, the expression of RANKL at both the mRNA and the protein level was investigated in chondroblastoma tumour tissue obtained from patients.