A novel HER2-positive breast cancer phenotype arising from germline TP53 mutations | Zendy

Jamie Wilson | Zendy; Adrian C Bateman | Zendy; Helen Hanson | Zendy; Qi An | Zendy; D. Gareth Evans | Zendy; Nazneen Rahman | Zendy; J. Louise Jones | Zendy; Diana Eccles | Zendy

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A novel HER2-positive breast cancer phenotype arising from germline TP53 mutations

Author(s) -

Jamie Wilson,

Adrian C Bateman,

Helen Hanson,

Qi An,

D. Gareth Evans,

Nazneen Rahman,

J. Louise Jones,

Diana Eccles

Publication year - 2010

Publication title -

journal of medical genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.439

H-Index - 170

eISSN - 1468-6244

pISSN - 0022-2593

DOI - 10.1136/jmg.2010.078113

Subject(s) - breast cancer , germline mutation , germline , mutation , male breast cancer , oncology , cancer , cancer research , biology , medicine , genetics , gene

The Li-Fraumeni Syndrome is caused by a germline TP53 mutation and is associated with a high risk of breast cancer at young ages. Basal (triple negative) breast cancers are now well recognised to be a typical sub-type of breast cancer developing in a large proportion of BRCA1 gene carriers. We considered whether a similar narrow sub-type of breast cancer was found in TP53 gene mutation carriers.

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