Open AccessSkewed X chromosome inactivation and early-onset breast cancer
Author(s) -
Jeffery P. Struewing,
Marbin Pineda,
Mark E. Sherman,
Jolanta Lissowska,
Louise A. Brinton,
Beata Pepłońska,
Alicja Bardin-Mikolajczak,
Montserrat GarcíaClosas
Publication year - 2005
Publication title -
journal of medical genetics (print)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.439
H-Index - 170
eISSN - 1468-6244
pISSN - 0022-2593
DOI - 10.1136/jmg.2005.033134
Subject(s) - hpaii , breast cancer , population , x inactivation , biology , chromosome , skewed x inactivation , cancer , medicine , x chromosome , genetics , oncology , gene , dna methylation , gene expression , environmental health
Skewed X chromosome inactivation may be more common in women with epithelial ovarian cancer and early-onset breast cancer. We tested this hypothesis in a group of 235 breast cancer patients and 253 controls (mean age 45.8 years) from a larger population based case control study.