Open AccessDiverse types of genomic evidence converge on alcohol use disorder risk genes
Author(s) -
Yulin Dai,
Ruifeng Hu,
Guangsheng Pei,
Huiping Zhang,
Zhongming Zhao,
Peilin Jia
Publication year - 2020
Publication title -
journal of medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.439
H-Index - 170
eISSN - 1468-6244
pISSN - 0022-2593
DOI - 10.1136/jmedgenet-2019-106490
Subject(s) - epigenetics , alcohol use disorder , genome wide association study , transcriptome , biology , dna methylation , genetics , gene , candidate gene , genetic association , bioinformatics , computational biology , gene expression , genotype , single nucleotide polymorphism , alcohol , biochemistry
Alcohol use disorder (AUD) is one of the most common forms of substance use disorders with a strong contribution of genetic (50%-60%) and environmental factors. Genome-wide association studies (GWAS) have identified a number of AUD-associated variants, including those in alcohol metabolism genes. These genetic variants may modulate gene expression, making individuals more susceptible to AUD. A long-term alcohol consumption can also change the transcriptome patterns of subjects via epigenetic modulations.