Open AccessExpression of the checkpoint receptors LAG-3, TIM-3 and VISTA in peripheral T cell lymphomas
Author(s) -
Carlos MurgaZamalloa,
Noah A. Brown,
Ryan A. Wilcox
Publication year - 2019
Publication title -
journal of clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 127
eISSN - 1472-4146
pISSN - 0021-9746
DOI - 10.1136/jclinpath-2019-206117
Subject(s) - t cell , biology , tumor microenvironment , receptor , cancer research , lymphoma , immunology , immune system , immune checkpoint , immunotherapy , biochemistry
Peripheral T cell lymphomas represent approximately 10%-15% of non-Hodgkin lymphomas and are characterised by an aggressive clinical courses and poor outcomes. Ligands provided by constituents of the tumour microenvironment engage receptors expressed by malignant T cells, promoting tumour growth and chemotherapy resistance. In addition to stimulatory receptors that promote the growth and survival of malignant T cells, recent studies suggest that homologous inhibitory receptors may have an opposing effect and function as tumour suppressors. For example, recent data suggest that programmed cell death 1 blockade may lead to increased lymphoma growth. Therefore, the identification of alternative checkpoint receptors in T cell lymphoproliferative neoplasms is an important and clinically relevant question.