Open AccessB-type natriuretic peptide and cardiac remodelling after myocardial infarction: a randomised trial
Author(s) -
Scott A. Hubers,
John A. Schirger,
S. Jeson Sangaralingham,
Yang Chen,
John C. Burnett,
David O. Hodge,
Horng H. Chen
Publication year - 2020
Publication title -
heart
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 183
eISSN - 1468-201X
pISSN - 1355-6037
DOI - 10.1136/heartjnl-2020-317182
Subject(s) - medicine , ejection fraction , myocardial infarction , cardiology , natriuretic peptide , ventricular remodeling , placebo , infarction , brain natriuretic peptide , heart failure , alternative medicine , pathology
B-type natriuretic peptide (BNP) has favourable effects on left ventricular remodelling, including antifibrotic and antiapoptotic properties. We tested the hypothesis that infusion of BNP after an acute myocardial infarction would reduce left ventricular systolic and diastolic volumes and improve left ventricular ejection fraction compared with placebo.