Open AccessHost and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies
Author(s) -
Qibin Qi,
Jun Li,
Bing Yu,
Jee Young Moon,
Jin Choul Chai,
Jordi Merino,
Jie Hu,
Miguel RuizCanela,
Casey M. Rebholz,
Zheng Wang,
Mykhaylo Usyk,
Guo Chong Chen,
Bianca Porneala,
Wenshuang Wang,
Ngoc Quynh Nguyen,
Elena V. Feofanova,
Megan L. Grove,
Thomas J. Wang,
Robert E. Gerszten,
Josée Dupuis,
Jordi SalasSalvadó,
Wei Bao,
David L. Perkins,
Martha L. Daviglus,
Bharat Thyagarajan,
Jianwen Cai,
Tao Wang,
Jo Ann E. Manson,
Miguel A. MartínezGonzález,
Elizabeth Selvin,
Kathryn M Rexrode,
Clary B. Clish,
Frank B. Hu,
James B. Meigs,
Rob Knight,
Robert D. Burk,
Eric Boerwinkle,
Robert C. Kaplan
Publication year - 2021
Publication title -
gut
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.413
H-Index - 293
eISSN - 1468-3288
pISSN - 0017-5749
DOI - 10.1136/gutjnl-2021-324053
Subject(s) - biology , gut flora , kynurenine , microbiome , tryptophan , type 2 diabetes , metabolome , bifidobacterium , metabolomics , microbiology and biotechnology , genetics , bacteria , diabetes mellitus , immunology , endocrinology , lactobacillus , bioinformatics , amino acid
Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut microbiota.