Open AccessChromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer
Author(s) -
Elias Orouji,
Ayush T. Raman,
Anand K. Singh,
Alexey V. Sorokin,
Emre Arslan,
Archit K. Ghosh,
Jonathan E. Schulz,
Christopher Terranova,
Shan Jiang,
Ming Tang,
Mayinuer Maitituoheti,
S. Carson Callahan,
Praveen Barrodia,
Katarzyna Tomczak,
Yingda Jiang,
Zhi-Qin Jiang,
Jennifer S. Davis,
Sukhen C. Ghosh,
Hey Min Lee,
Laura Reyes-Uribe,
Kyle Chang,
Yusha Liu,
Huiqin Chen,
Ali Azhdarinia,
Jeffrey S. Morris,
Eduardo Vilar,
Kendra S. Carmon,
Scott Kopetz,
Kunal Rai
Publication year - 2021
Publication title -
gut
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.413
H-Index - 293
eISSN - 1468-3288
pISSN - 0017-5749
DOI - 10.1136/gutjnl-2020-322835
Subject(s) - enhancer , epigenomics , h3k4me3 , chromatin , epigenome , epigenetics , biology , cancer research , bromodomain , histone , enhancer rnas , colorectal cancer , ezh2 , genetics , dna methylation , computational biology , cancer , promoter , transcription factor , gene expression , gene
Enhancer aberrations are beginning to emerge as a key epigenetic feature of colorectal cancers (CRC), however, a comprehensive knowledge of chromatin state patterns in tumour progression, heterogeneity of these patterns and imparted therapeutic opportunities remain poorly described.