Open AccessMultiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions
Author(s) -
Kohei Fujikura,
Waki Hosoda,
Matthäus Felsenstein,
Qianqian Song,
Johannes Reiter,
Lily Zheng,
Violeta Beleva Guthrie,
Natalia Rincon,
Marco Dal Molin,
Jonathan C. Dudley,
Joshua D. Cohen,
Pei Wang,
Catherine G. Fischer,
Alicia M. Braxton,
Michaël Noë,
Martine Jongepier,
Carlos Fernández-Del Castillo,
Mari MinoKenudson,
C. Max Schmidt,
Michele Yip-Schneider,
Rita T. Lawlor,
Roberto Salvia,
Nicholas J. Roberts,
Elizabeth D. Thompson,
Rachel Karchin,
Anne Marie Len,
Yuchen Jiao,
Laura D. Wood
Publication year - 2020
Publication title -
gut
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.413
H-Index - 293
eISSN - 1468-3288
pISSN - 0017-5749
DOI - 10.1136/gutjnl-2020-321217
Subject(s) - dysplasia , exome sequencing , biology , exome , pathology , klf4 , germline mutation , genetics , medicine , mutation , gene , embryonic stem cell , induced pluripotent stem cell
Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor lesions that can progress to invasive pancreatic cancer and are classified as low-grade or high-grade based on the morphology of the neoplastic epithelium. We aimed to compare genetic alterations in low-grade and high-grade regions of the same IPMN in order to identify molecular alterations underlying neoplastic progression.