Open AccessFunctional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity
Author(s) -
Katharina Herzog,
Simonetta Bandiera,
Sophie Pernot,
Catherine Fauvelle,
Frank Jühling,
Amélie Weiss,
Anne Bull,
Sarah Durand,
Béatrice Chane-Woon-Ming,
Sébastien Pfeffer,
Marion Mercey,
Hervé Lerat,
Jean-Christophe Meunier,
Wolfgang Raffelsberger,
Laurent Brino,
Thomas F. Baumert,
Mirjam B. Zeisel
Publication year - 2019
Publication title -
gut
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.413
H-Index - 293
eISSN - 1468-3288
pISSN - 0017-5749
DOI - 10.1136/gutjnl-2018-317423
Subject(s) - microrna , hepatitis c virus , infectivity , biology , virus , morphogenesis , gene , viral life cycle , virology , microbiology and biotechnology , genetics , viral replication
Infection of human hepatocytes by the hepatitis C virus (HCV) is a multistep process involving both viral and host factors. microRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Given that miRNAs were indicated to regulate between 30% and 75% of all human genes, we aimed to investigate the functional and regulatory role of miRNAs for the HCV life cycle.