Open AccessLoss of interstitial cells and a fibromuscular layer on the luminal side of the colonic circular muscle presenting as megacolon in an adult patient
Author(s) -
Maria Simonetta FaussonePellegrini,
Paolo Fociani,
Roberto Buffa,
Guido Basilisco
Publication year - 1999
Publication title -
gut
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.413
H-Index - 293
eISSN - 1468-3288
pISSN - 0017-5749
DOI - 10.1136/gut.45.5.775
Subject(s) - interstitial cell of cajal , megacolon , pathology , ascending colon , sigmoid colon , immunocytochemistry , medicine , anatomy , biology , immunohistochemistry , rectum
Animal studies have shown that the neuromuscular structures on the luminal side of the colonic circular muscle coordinate circular muscle activity. These structures have been identified by electron microscopy in the normal human colon, but have never been thoroughly studied in patients with acquired intestinal hypoganglionosis.