The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia | Zendy

Ryan M. Thomas | Zendy; J Kim | Zendy; Monica P. Revelo-Penafiel | Zendy; R Angel | Zendy; D W Dawson | Zendy; Andrew M. Lowy | Zendy

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The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia

Author(s) -

Ryan M. Thomas,

J Kim,

Monica P. Revelo-Penafiel,

R Angel,

D W Dawson,

Andrew M. Lowy

Publication year - 2008

Publication title -

gut

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.413

H-Index - 293

eISSN - 1468-3288

pISSN - 0017-5749

DOI - 10.1136/gut.2007.143941

Subject(s) - chemokine receptor , pancreatic intraepithelial neoplasia , cxcr4 , chemokine , medicine , cancer research , receptor , pancreatic cancer , pancreatic ductal adenocarcinoma , cancer

The chemokine CXCL12, together with its specific receptor, CXCR4, have been shown to mediate invasiveness and metastatic behaviour in pancreatic cancer cells. The expression of CXC12/CXCR4 has not been previously examined in pancreatic intraepithelial neoplasias (PanIN), the accepted precursor lesions to pancreatic duct cancer.

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