Open AccessThe chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia
Author(s) -
Ryan M. Thomas,
Joseph Kim,
Monica P. Revelo-Penafiel,
Rita Angel,
David D. Dawson,
Andrew M. Lowy
Publication year - 2008
Publication title -
gut
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.413
H-Index - 293
eISSN - 1468-3288
pISSN - 0017-5749
DOI - 10.1136/gut.2007.143941
Subject(s) - chemokine receptor , pancreatic intraepithelial neoplasia , cxcr4 , chemokine , medicine , cancer research , receptor , pancreatic cancer , pancreatic ductal adenocarcinoma , cancer
The chemokine CXCL12, together with its specific receptor, CXCR4, have been shown to mediate invasiveness and metastatic behaviour in pancreatic cancer cells. The expression of CXC12/CXCR4 has not been previously examined in pancreatic intraepithelial neoplasias (PanIN), the accepted precursor lesions to pancreatic duct cancer.