Open AccessMetronidazole- and levofloxacin-induced psychotic disorders in chronic kidney patient
Author(s) -
Radmila Veličković–Radovanović,
Aleksandra CatićĐorđević,
Katarina Dinić,
Jasmina Radivojević,
Olivera Žikić,
Tatjana Cvetković,
Branka Mitić
Publication year - 2018
Publication title -
european journal of hospital pharmacy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.313
H-Index - 14
eISSN - 2047-9964
pISSN - 2047-9956
DOI - 10.1136/ejhpharm-2018-001677
Subject(s) - levofloxacin , medicine , metronidazole , discontinuation , peritoneal dialysis , delirium , neurotoxicity , surgery , antibiotics , intensive care medicine , toxicity , microbiology and biotechnology , biology
We present a case which reports the occurrence of psychotic disorders after metronidazole and levofloxacin therapy in a chronic kidney patient while being treated for enterocolitis and urinary infection. A 48-year-old female was admitted to a hospital for the placement of a peritoneal dialysis catheter due to indicated peritoneal dialysis. During admission, symptoms of enterocolitis and urinary infection had occurred, so metronidazole and levofloxacin were introduced into therapy, respectively. After 4 days of metronidazole and 3 days of levofloxacin therapy, the patient became confused, disoriented, with signs of delirium. Since the diagnosis of psychoorganic disorder was made, the therapy with lorazepam and haloperidol was initiated, while metronidazole and levofloxacin were discontinued. Complete recovery 4 days after discontinuation indicates that the patient has experienced antibiotics-induced neurotoxicity. This is the first report of expressed neurotoxicity after the combination of metronidazole and levofloxacin in chronic kidney patients.