Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma | Zendy

Henrike Westekemper | Zendy; S. Karimi | Zendy; Daniela Süßkind | Zendy; Gerasimos Anastassiou | Zendy; M. Freistuhler | Zendy; KlausPeter Steuhl | Zendy; Norbert Bornfeld | Zendy; K. W. Schmid | Zendy; Florian Grabellus | Zendy

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Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma

Author(s) -

Henrike Westekemper,

S. Karimi,

Daniela Süßkind,

Gerasimos Anastassiou,

M. Freistuhler,

KlausPeter Steuhl,

Norbert Bornfeld,

K. W. Schmid,

Florian Grabellus

Publication year - 2010

Publication title -

british journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.016

H-Index - 153

eISSN - 1468-2079

pISSN - 0007-1161

DOI - 10.1136/bjo.2010.183939

Subject(s) - pten , tensin , immunohistochemistry , medicine , melanoma , pathology , cancer research , conjunctiva , biology , apoptosis , pi3k/akt/mtor pathway , biochemistry

In conjunctival melanoma, little is known about the tumour biology and protein-expression patterns. In this study, the authors analysed the expression of the antiapoptotic oncoprotein B cell leukaemia/lymphoma-2 protein (Bcl-2), the tumour-suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN), and the heat-shock-protein HSP-90 in conjunctival melanoma (CoM) and conjunctival nevi (CoN) by immunohistochemistry (IHC).

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