Acute hepatitis induced by glatiramer acetate | Zendy

Pierre Deltenre | Zendy; M O Peny | Zendy; A. Dufour | Zendy; Mohamed M. El Nady | Zendy; Jean Henrion | Zendy

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Acute hepatitis induced by glatiramer acetate

Author(s) -

Pierre Deltenre,

M O Peny,

A. Dufour,

Mohamed M. El Nady,

Jean Henrion

Publication year - 2009

Publication title -

bmj case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.231

H-Index - 26

ISSN - 1757-790X

DOI - 10.1136/bcr.09.2008.0913

Subject(s) - medicine , glatiramer acetate , acute hepatitis , hepatitis , intensive care medicine , multiple sclerosis , pharmacology , immunology

Glatiramer acetate, a mixture of synthetic polypeptides able to prevent autoimmune encephalomyelitis in experimental models, is used as a treatment for patients with active relapsing-remitting multiple sclerosis. We report one case of glatiramer acetate induced hepatitis. Liver biopsy was consistent with a diagnosis of drug induced hepatitis and alanine aminotransferase returned to normal values after treatment discontinuation. The present case should serve as a warning that glatiramer acetate may cause acute liver disease.

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