Open AccessIsochromosome 9q as a sole anomaly in an Omani boy with acute lymphoblastic leukaemia
Author(s) -
Udayakumar Muthappa Achandira,
Anil Pathare,
Salam Al Kindi,
David Dennison,
S. Al Yahyaee
Publication year - 2009
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr.09.2008.0890
Subject(s) - isochromosome , medicine , immunophenotyping , bone marrow , cytogenetics , pathology , gastroenterology , karyotype , immunology , genetics , chromosome , flow cytometry , gene , biology
This report describes a case of acute lymphoblastic leukaemia in which isochromosome 9q (i(9q)) was the sole acquired cytogenetic abnormality. The Immunophenotype showed positivity for CD3, CD4, CD5, CD7, CD8, CD10, CD71, CD117 and TdT, consistent with T cell acute lymphoblastic leukaemia (ALL). The chromosomal analysis of bone marrow showed 46,XY,i(9)(q10) in all the metaphases analysed. The bone marrow morphology was ALL-L2 as per the French-American-British criteria. Isochromosomes are rare chromosomal abnormalities in childhood ALL and the effect of i(9q) is not well established. The patient's good response to therapy with normal cytogenetics within a month of induction, and disease-free survival after bone marrow transplant are indicative of a good prognosis in such cases.