Open AccessHypocretinergic dysfunction in neuromyelitis optica with coma-like episodes
Author(s) -
Bertrand Carlander,
Thierry Vincent,
A Le Floch,
Nicolas Pageot,
William Camu,
Yves Dauvilliers
Publication year - 2009
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr.08.2008.0709
Subject(s) - neuromyelitis optica , medicine , dysautonomia , multiple sclerosis , spinal cord , cerebrospinal fluid , demyelinating disorder , neurology , demyelinating disease , optic neuritis , central nervous system , disease , coma (optics) , pathology , immunology , psychiatry , physics , optics
Devic's neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system, often misdiagnosed as multiple sclerosis, and involving mainly optic nerves and the spinal cord. We report on a peculiar case of relapsing NMO with severe recurrent dysautonomia and hypersomnia, in which we had the opportunity to observe a dramatic decrease in hypocretin/orexin cerebrospinal fluid level.