Hypocretinergic dysfunction in neuromyelitis optica with coma-like episodes | Zendy

Bertrand Carlander | Zendy; Thierry Vincent | Zendy; A Le Floch | Zendy; N. Pageot | Zendy; William Camu | Zendy; Yves Dauvilliers | Zendy

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Hypocretinergic dysfunction in neuromyelitis optica with coma-like episodes

Author(s) -

Bertrand Carlander,

Thierry Vincent,

A Le Floch,

N. Pageot,

William Camu,

Yves Dauvilliers

Publication year - 2009

Publication title -

bmj case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.231

H-Index - 26

ISSN - 1757-790X

DOI - 10.1136/bcr.08.2008.0709

Subject(s) - neuromyelitis optica , medicine , dysautonomia , multiple sclerosis , spinal cord , cerebrospinal fluid , demyelinating disorder , neurology , demyelinating disease , optic neuritis , central nervous system , disease , coma (optics) , pathology , immunology , psychiatry , physics , optics

Devic's neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system, often misdiagnosed as multiple sclerosis, and involving mainly optic nerves and the spinal cord. We report on a peculiar case of relapsing NMO with severe recurrent dysautonomia and hypersomnia, in which we had the opportunity to observe a dramatic decrease in hypocretin/orexin cerebrospinal fluid level.

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