Travoprost and latanoprost, but not bimatoprost, induced nausea, vomiting and diarrhoea

A 46-year-old woman with glaucoma secondary to chronic iridocyclitis complained of nausea, vomiting and diarrhoea upon topical application of travoprost and latanoprost. Unmasked dechallenge and rechallenge with both travoprost and latanoprost were carried out. Challenge with bimatoprost on both eyes was also performed. Travoprost and latanoprost, but not bimatoprost, induced nausea, vomiting and diarrhoea. Based on the findings of unmasked dechallenge and rechallenge, nausea, vomiting and sometimes diarrhoea should be considered as adverse effects of travoprost and latanoprost. In this report, bimatoprost did not induce the same gastrointestinal adverse effects, probably due to its different chemical structure and receptors.