Open AccessNew formulation of Botox: complete antibody-induced treatment failure in cervical dystonia
Author(s) -
Dirk Dressler,
Fereshte Adib Saberi
Publication year - 2009
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr.08.2008.0611
Subject(s) - medicine , cervical dystonia , botulinum toxin , potency , dystonia , antibody , surgery , immunology , biochemistry , chemistry , in vitro , psychiatry
Botulinum toxin is used with remarkable success to treat various muscle and exocrine gland hyperactivity syndromes. Rarely, treatment failure due to formation of botulinum toxin antibodies (ABF) occurs. To reduce the risk of ABF, a new formulation of Botox (in the following "current Botox"; Allergan, Irvine, California, USA) with increased specific biological potency was introduced. Here we report the case of a 50-year-old woman who developed ABF despite receiving current Botox.