Chronic valproic acid intoxication: reversal by naloxone | Zendy

Ruben Thanacoody | Zendy

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Chronic valproic acid intoxication: reversal by naloxone

Author(s) -

Ruben Thanacoody

Publication year - 2009

Publication title -

bmj case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.231

H-Index - 26

ISSN - 1757-790X

DOI - 10.1136/bcr.06.2009.1924

Subject(s) - medicine , valproic acid , (+) naloxone , anesthesia , depression (economics) , confusion , toxicity , liter , myoclonus , epilepsy , psychiatry , opioid , psychology , receptor , psychoanalysis , economics , macroeconomics

A 76-year-old woman being treated with sodium valproate for bipolar depression presented with a 4-day history of acute confusion and tremulousness. She had apnoeic episodes, a reduced conscious level and generalised myoclonic movements. Her plasma valproate concentration was 848 μmol/litre (normal range 300-600 μmol/litre). Administration of naloxone 0.8 mg led to rapid clinical improvement. Naloxone may be useful in reversing the features of chronic valproate toxicity.

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