Open AccessA case of rapid-growing anaplastic meningiomas
Author(s) -
Athanasios K. Petridis,
Alexandros Doukas,
Mehran Mahvash,
Lutz Dörner,
Heinz-Hermann Hugo,
H. Maximilian Mehdorn
Publication year - 2009
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr.05.2009.1862
Subject(s) - medicine , meningioma , mitotic index , pathology , frontal lobe , radiology , oncology , mitosis , psychiatry , biology , microbiology and biotechnology
Meningiomas are tumours originating from the leptomeningeal covering of the brain and spinal cord and are generally benign and slow growing. Rarely, they show malignant anaplastic characteristics with a high recurrence rate. A number of factors have been reported to predict this high recurrence. Such factors are histopathological ones, such as necrosis and hypercellularity, the World Health Organization (WHO) grade, mitotic index, positivity of proliferation markers (Ki-67 or MIB-1), clinical parameters such as age, gender, localisation, cytogenetic factors and radiation treatment. The present case reports a patient with a giant meningioma over the right frontal lobe who had almost all possible negative prognostic parameters and showed an explosive multifocal recurrence in a timespan of about 5 months.