Open AccessInteresting case of dual pathology: Crohn’s disease and Peutz-Jeghers syndrome
Author(s) -
Mantej Sehmbhi,
Penelope Sellers,
Jonathan Segal,
Susan Clark
Publication year - 2020
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2020-234513
Subject(s) - medicine , peutz–jeghers syndrome , intussusception (medical disorder) , colonoscopy , infliximab , crohn's disease , inflammatory bowel disease , weight loss , disease , rare disease , tuberculosis , dermatology , gastroenterology , surgery , pathology , colorectal cancer , cancer , obesity
An 18-year-old man presented with fever, night sweats and progressive weight loss over 2 months. He had a history of Peutz-Jeghers syndrome (PJS) complicated by previous intussusception requiring left hemicolectomy. Colonoscopy revealed deep punched out ulceration throughout the colon with multiple polyps. He was investigated for tuberculosis based on his occupation as dairy farmer. Following a negative QuantiFERON test, he was started on infliximab as emergency therapy and made a good recovery at 6 months follow-up. We describe a case of newly diagnosed Crohn's disease (CD) in an adolescent with a background diagnosis of PJS. While inflammatory bowel disease, such as CD, is common in the UK, the association with PJS is very rare, with only two existing case reports in the literature.