Open AccessPersistent sore throat: a case of laryngeal mucous membrane pemphigoid
Author(s) -
Sarah Law,
Jeni Pillai,
Christopher Burgess
Publication year - 2020
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2019-233566
Subject(s) - medicine , sore throat , epiglottis , cicatricial pemphigoid , biopsy , dermatology , mucous membrane , throat , larynx , airway , airway obstruction , laryngoscopy , surgery , pemphigoid , pathology , bullous pemphigoid , antibody , immunology , intubation
We present a case of a 72-year-old women who presented with a persistent sore throat and productive cough. On flexible nasendoscopy examination, she was found to have a fairly superficial ulcer affecting the laryngeal surface and tip of her epiglottis. On her second microlaryngoscopy and biopsy, direct immunofluorescent staining of the biopsy was analysed and the histological findings were in keeping with a diagnosis of mucous membrane pemphigoid (MMP). MMP is a rare chronic autoimmune condition characterised by the presence of blistering subepithelial lesions that can cause scarring. Laryngeal MMP affects only 1 in 10 million people and can lead to life-threatening airway compromise arising from scarring and stenosis. As there is a large spectrum of disease, it is important to adopt a multidisciplinary approach including dermatologists, otolaryngologists and ophthalmologists for prompt diagnosis and early recognition of potential complications, maximising functional outcomes for patients.