Open AccessStatin-induced necrotising autoimmune myopathy and autoimmune hepatitis presenting with dysphagia
Author(s) -
Osama Qasim Agha,
Sukhdeep Kaur,
Nirmal Vijayavel
Publication year - 2020
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2019-232391
Subject(s) - medicine , autoimmune hepatitis , muscle biopsy , dysphagia , liver biopsy , myopathy , gastroenterology , biopsy , creatine kinase , inflammatory myopathy , statin , autoimmune disease , pathology , hepatitis , disease , surgery
Statin-induced necrotising autoimmune myopathy (SINAM) is a rare disease characterised by proximal muscle weakness and elevated creatine kinase levels that is usually in the thousands. Anti-3-hydroxy-3-methyl glutaryl co-enzyme A reductase (HMGCR) antibodies are associated with SINAM. Autoimmune hepatitis (AIH) is an inflammatory disease of the liver that is usually of unknown aetiology but can also be associated with concurrent extrahepatic autoimmune disorders. We are reporting a case of biopsy proven AIH associated with SINAM in a patient presenting with oropharyngeal dysphagia. The patient had elevated anti-HMGCR antibodies and anti-smooth muscle antibodies. SINAM and AIH were confirmed by muscle biopsy and liver biopsy, respectively. The patient had complete resolution of his symptoms and complete normalisation of his liver function tests after 6 months of the treatment.